Pivoted full data

En este documento se crean las tablas para las predicciones.

	AGE_Y	WEIGHT_KG	HEIGHT_CM	GENDER_CODE	furosemide	chlorpromazine	cephalothin	chlordiazepoxide hydrochloride	fursemide	hydralazine hydrochloride	...	Pregnancy, puerperium and perinatal conditions	Product issues	Psychiatric disorders	Renal and urinary disorders	Reproductive system and breast disorders	Respiratory, thoracic and mediastinal disorders	Skin and subcutaneous tissue disorders	Social circumstances	Surgical and medical procedures	Vascular disorders
REPORT_ID
164	68.0	47.000000	173.00	0	1	1	2	2	1	1	...	0	0	0	0	0	0	0	0	0	0
173	42.0	82.000000	180.00	0	0	0	2	0	0	0	...	0	0	0	0	0	0	0	0	0	0
180	29.0	77.652228	165.00	1	0	0	0	0	0	0	...	0	0	0	0	0	0	0	0	0	0
346	59.0	62.400000	159.70	1	0	0	2	0	0	0	...	0	0	0	0	0	0	1	0	0	0
356	21.0	60.000000	164.52	1	0	0	0	0	0	0	...	0	0	0	0	0	0	0	0	0	0

5 rows × 9120 columns

<class 'pandas.core.frame.DataFrame'>
Index: 17854 entries, 164 to 908149644
Columns: 9093 entries, AGE_Y to 
dtypes: float64(3), int32(2), uint32(9088)
memory usage: 619.6 MB
None
<class 'pandas.core.frame.DataFrame'>
Index: 17854 entries, 164 to 908149644
Columns: 9093 entries, AGE_Y to 
dtypes: float64(3), int8(9090)
memory usage: 155.3 MB
None

	Blood and lymphatic system disorders	Cardiac disorders	Congenital, familial and genetic disorders	Ear and labyrinth disorders	Endocrine disorders	Eye disorders	Gastrointestinal disorders	General disorders and administration site conditions	Hepatobiliary disorders	Immune system disorders	...	Pregnancy, puerperium and perinatal conditions	Product issues	Psychiatric disorders	Renal and urinary disorders	Reproductive system and breast disorders	Respiratory, thoracic and mediastinal disorders	Skin and subcutaneous tissue disorders	Social circumstances	Surgical and medical procedures	Vascular disorders
REPORT_ID
164	0	0	0	0	0	1	0	0	0	0	...	0	0	0	0	0	0	0	0	0	0
173	0	0	0	0	0	0	0	0	0	0	...	0	0	0	0	0	0	0	0	0	0
180	0	0	0	0	0	0	1	0	0	0	...	0	0	0	0	0	0	0	0	0	0
346	0	0	0	0	0	0	0	0	0	0	...	0	0	0	0	0	0	1	0	0	0
356	0	0	0	0	0	0	1	0	0	0	...	0	0	0	0	0	0	0	0	0	0

5 rows × 27 columns

	AGE_Y	WEIGHT_KG	HEIGHT_CM	GENDER_CODE	furosemide	chlorpromazine	cephalothin	chlordiazepoxide hydrochloride	fursemide	hydralazine hydrochloride	...	prunus cerasus extract	prunus cerasus root	prunus cerasus bark	cilgavimab	tixagevimab	daratumumab (humax-cd38)	sigvotatug vedotin	cephalosporin nos	ravulizumab
REPORT_ID
164	68.0	47.000000	173.00	0	1	1	2	2	1	1	...	0	0	0	0	0	0	0	0	0	0
173	42.0	82.000000	180.00	0	0	0	2	0	0	0	...	0	0	0	0	0	0	0	0	0	0
180	29.0	77.652228	165.00	1	0	0	0	0	0	0	...	0	0	0	0	0	0	0	0	0	0
346	59.0	62.400000	159.70	1	0	0	2	0	0	0	...	0	0	0	0	0	0	0	0	0	0
356	21.0	60.000000	164.52	1	0	0	0	0	0	0	...	0	0	0	0	0	0	0	0	0	0

5 rows × 9093 columns

Model

Number of features: 9093, Number of SOCs: 27

=== Training model for SOC: Blood and lymphatic system disorders (1/27) ===
0:	test: 0.6263969	best: 0.6263969 (0)	total: 42.4ms	remaining: 170ms
4:	test: 0.7170507	best: 0.7170507 (4)	total: 84.5ms	remaining: 0us
bestTest = 0.7170507014
bestIteration = 4

=== Training model for SOC: Cardiac disorders (2/27) ===
0:	test: 0.6296576	best: 0.6296576 (0)	total: 7.47ms	remaining: 29.9ms
4:	test: 0.7043951	best: 0.7043951 (4)	total: 34.8ms	remaining: 0us
bestTest = 0.7043951452
bestIteration = 4

=== Training model for SOC: Congenital, familial and genetic disorders (3/27) ===
0:	test: 0.7595760	best: 0.7595760 (0)	total: 9.3ms	remaining: 37.2ms
4:	test: 0.8402794	best: 0.8434915 (3)	total: 41.7ms	remaining: 0us
bestTest = 0.8434915245
bestIteration = 3
Shrink model to first 4 iterations.

=== Training model for SOC: Ear and labyrinth disorders (4/27) ===
0:	test: 0.6930045	best: 0.6930045 (0)	total: 7.63ms	remaining: 30.5ms
4:	test: 0.6857546	best: 0.6973837 (2)	total: 38.3ms	remaining: 0us
bestTest = 0.6973837316
bestIteration = 2
Shrink model to first 3 iterations.

=== Training model for SOC: Endocrine disorders (5/27) ===
0:	test: 0.7711140	best: 0.7711140 (0)	total: 8.55ms	remaining: 34.2ms
4:	test: 0.8200512	best: 0.9286556 (2)	total: 41.5ms	remaining: 0us
bestTest = 0.9286555648
bestIteration = 2
Shrink model to first 3 iterations.

=== Training model for SOC: Eye disorders (6/27) ===
0:	test: 0.6487707	best: 0.6487707 (0)	total: 8.47ms	remaining: 33.9ms
4:	test: 0.6980752	best: 0.6980752 (4)	total: 40.7ms	remaining: 0us
bestTest = 0.6980751753
bestIteration = 4

=== Training model for SOC: Gastrointestinal disorders (7/27) ===
0:	test: 0.5854751	best: 0.5854751 (0)	total: 26.1ms	remaining: 105ms
4:	test: 0.6118187	best: 0.6156444 (3)	total: 128ms	remaining: 0us
bestTest = 0.6156444252
bestIteration = 3
Shrink model to first 4 iterations.

=== Training model for SOC: General disorders and administration site conditions (8/27) ===
0:	test: 0.6391513	best: 0.6391513 (0)	total: 22.1ms	remaining: 88.5ms
4:	test: 0.6529090	best: 0.6580369 (3)	total: 112ms	remaining: 0us
bestTest = 0.6580368876
bestIteration = 3
Shrink model to first 4 iterations.

=== Training model for SOC: Hepatobiliary disorders (9/27) ===
0:	test: 0.6869444	best: 0.6869444 (0)	total: 23.9ms	remaining: 95.8ms
4:	test: 0.7036905	best: 0.7036905 (4)	total: 118ms	remaining: 0us
bestTest = 0.7036904991
bestIteration = 4

=== Training model for SOC: Immune system disorders (10/27) ===
0:	test: 0.6784772	best: 0.6784772 (0)	total: 17.9ms	remaining: 71.4ms
4:	test: 0.7141991	best: 0.7141991 (4)	total: 90.1ms	remaining: 0us
bestTest = 0.7141990662
bestIteration = 4

=== Training model for SOC: Infections and infestations (11/27) ===
0:	test: 0.7119369	best: 0.7119369 (0)	total: 11.6ms	remaining: 46.5ms
4:	test: 0.7292608	best: 0.7292608 (4)	total: 53.8ms	remaining: 0us
bestTest = 0.7292607725
bestIteration = 4

=== Training model for SOC: Injury, poisoning and procedural complications (12/27) ===
0:	test: 0.7072273	best: 0.7072273 (0)	total: 11.4ms	remaining: 45.8ms
4:	test: 0.7511556	best: 0.7511556 (4)	total: 44.7ms	remaining: 0us
bestTest = 0.7511556447
bestIteration = 4

=== Training model for SOC: Investigations (13/27) ===
0:	test: 0.7063534	best: 0.7063534 (0)	total: 9.61ms	remaining: 38.4ms
4:	test: 0.7441803	best: 0.7441803 (4)	total: 44ms	remaining: 0us
bestTest = 0.7441803217
bestIteration = 4

=== Training model for SOC: Metabolism and nutrition disorders (14/27) ===
0:	test: 0.6128425	best: 0.6128425 (0)	total: 23.9ms	remaining: 95.6ms
4:	test: 0.7083851	best: 0.7083851 (4)	total: 134ms	remaining: 0us
bestTest = 0.7083850503
bestIteration = 4

=== Training model for SOC: Musculoskeletal and connective tissue disorders (15/27) ===
0:	test: 0.7202743	best: 0.7202743 (0)	total: 11.5ms	remaining: 45.9ms
4:	test: 0.7651218	best: 0.7651218 (4)	total: 56.5ms	remaining: 0us
bestTest = 0.7651218176
bestIteration = 4

=== Training model for SOC: Neoplasms benign, malignant and unspecified (incl cysts and polyps) (16/27) ===
0:	test: 0.7370589	best: 0.7370589 (0)	total: 12ms	remaining: 48.1ms
4:	test: 0.7613381	best: 0.7613381 (4)	total: 64.8ms	remaining: 0us
bestTest = 0.7613381147
bestIteration = 4

=== Training model for SOC: Nervous system disorders (17/27) ===
0:	test: 0.5651106	best: 0.5651106 (0)	total: 23.8ms	remaining: 95.4ms
4:	test: 0.5992123	best: 0.5992123 (4)	total: 106ms	remaining: 0us
bestTest = 0.599212274
bestIteration = 4

=== Training model for SOC: Pregnancy, puerperium and perinatal conditions (18/27) ===
0:	test: 0.8995284	best: 0.8995284 (0)	total: 21.6ms	remaining: 86.3ms
4:	test: 0.9462472	best: 0.9485448 (2)	total: 98.9ms	remaining: 0us
bestTest = 0.9485448301
bestIteration = 2
Shrink model to first 3 iterations.

=== Training model for SOC: Product issues (19/27) ===
0:	test: 0.6886626	best: 0.6886626 (0)	total: 10.3ms	remaining: 41.2ms
4:	test: 0.7354512	best: 0.7354512 (4)	total: 48.8ms	remaining: 0us
bestTest = 0.7354512215
bestIteration = 4

=== Training model for SOC: Psychiatric disorders (20/27) ===
0:	test: 0.6236721	best: 0.6236721 (0)	total: 13.9ms	remaining: 55.5ms
4:	test: 0.6502540	best: 0.6585685 (3)	total: 59.7ms	remaining: 0us
bestTest = 0.6585685164
bestIteration = 3
Shrink model to first 4 iterations.

=== Training model for SOC: Renal and urinary disorders (21/27) ===
0:	test: 0.7074958	best: 0.7074958 (0)	total: 23.8ms	remaining: 95.2ms
4:	test: 0.7328501	best: 0.7328501 (4)	total: 111ms	remaining: 0us
bestTest = 0.7328501344
bestIteration = 4

=== Training model for SOC: Reproductive system and breast disorders (22/27) ===
0:	test: 0.7315862	best: 0.7315862 (0)	total: 21.6ms	remaining: 86.6ms
4:	test: 0.7723102	best: 0.7833396 (2)	total: 99.9ms	remaining: 0us
bestTest = 0.7833396196
bestIteration = 2
Shrink model to first 3 iterations.

=== Training model for SOC: Respiratory, thoracic and mediastinal disorders (23/27) ===
0:	test: 0.6767372	best: 0.6767372 (0)	total: 14.3ms	remaining: 57.4ms
4:	test: 0.7035421	best: 0.7035421 (4)	total: 70.5ms	remaining: 0us
bestTest = 0.7035420537
bestIteration = 4

=== Training model for SOC: Skin and subcutaneous tissue disorders (24/27) ===
0:	test: 0.6928557	best: 0.6928557 (0)	total: 22.6ms	remaining: 90.5ms
4:	test: 0.7098036	best: 0.7098036 (4)	total: 108ms	remaining: 0us
bestTest = 0.7098036408
bestIteration = 4

=== Training model for SOC: Social circumstances (25/27) ===
0:	test: 0.7419802	best: 0.7419802 (0)	total: 18.2ms	remaining: 72.7ms
4:	test: 0.7535817	best: 0.7964436 (1)	total: 99.8ms	remaining: 0us
bestTest = 0.7964435518
bestIteration = 1
Shrink model to first 2 iterations.

=== Training model for SOC: Surgical and medical procedures (26/27) ===
0:	test: 0.6967070	best: 0.6967070 (0)	total: 8.98ms	remaining: 35.9ms
4:	test: 0.7807937	best: 0.7807937 (4)	total: 37.9ms	remaining: 0us
bestTest = 0.7807936668
bestIteration = 4

=== Training model for SOC: Vascular disorders (27/27) ===
0:	test: 0.6177105	best: 0.6177105 (0)	total: 17.6ms	remaining: 70.4ms
4:	test: 0.6484150	best: 0.6491412 (3)	total: 84.7ms	remaining: 0us
bestTest = 0.6491412222
bestIteration = 3
Shrink model to first 4 iterations.

Metrics

	SOC	prevalence_valid	AUC	AP	F1_thr_0.5
23	Skin and subcutaneous tissue disorders	0.406495	0.709804	0.631514	0.535088
7	General disorders and administration site cond...	0.336506	0.658037	0.526365	0.494327
6	Gastrointestinal disorders	0.217805	0.615644	0.346264	0.358238
10	Infections and infestations	0.208287	0.729261	0.412187	0.471969
22	Respiratory, thoracic and mediastinal disorders	0.184211	0.703542	0.444026	0.444149
12	Investigations	0.165174	0.744180	0.362319	0.418552
16	Nervous system disorders	0.148936	0.599212	0.245829	0.240000
11	Injury, poisoning and procedural complications	0.110302	0.751156	0.324896	0.376761
14	Musculoskeletal and connective tissue disorders	0.107503	0.765122	0.351955	0.391304
26	Vascular disorders	0.101904	0.649141	0.256053	0.275862
9	Immune system disorders	0.100224	0.714199	0.343235	0.339552
0	Blood and lymphatic system disorders	0.089026	0.717051	0.256670	0.281690
19	Psychiatric disorders	0.079507	0.658569	0.241618	0.268657
1	Cardiac disorders	0.061030	0.704395	0.227362	0.207059
13	Metabolism and nutrition disorders	0.059910	0.708385	0.210244	0.190889
20	Renal and urinary disorders	0.055431	0.732850	0.142909	0.191736
5	Eye disorders	0.041993	0.698075	0.266146	0.150000
3	Ear and labyrinth disorders	0.028555	0.697384	0.307482	0.222222
25	Surgical and medical procedures	0.020717	0.780794	0.128172	0.119122
8	Hepatobiliary disorders	0.020157	0.703690	0.180186	0.085437

Validation

Micro F1 (thr=0.75): 0.003
Macro F1 (thr=0.75): 0.002
False Positives (thr=0.75): 0
False Positive Rate (thr=0.75): 0.000
True Negative Rate (thr=0.75): 1.000
Positive Predictive Value (thr=0.75): 1.000
Accuracy (thr=0.75): 0.000

Max FPR: 1.000, at threshold 0.000
Max TNR: 1.000, at threshold 0.727
Max PPV: 1.000, at threshold 0.727
Max Macro F1: 0.256, at threshold 0.535
Max Micro F1: 0.330, at threshold 0.515
Max Accuracy: 0.074, at threshold 0.576

Best treshold for each one

	best_tau	best_F1
SOC
Blood and lymphatic system disorders	0.52	0.294118
Cardiac disorders	0.54	0.244444
Congenital, familial and genetic disorders	0.64	0.250000
Ear and labyrinth disorders	0.62	0.354839
Endocrine disorders	0.64	0.307692
Eye disorders	0.56	0.333333
Gastrointestinal disorders	0.49	0.376701
General disorders and administration site conditions	0.49	0.528503
Hepatobiliary disorders	0.58	0.222222
Immune system disorders	0.55	0.378531
Infections and infestations	0.50	0.471969
Injury, poisoning and procedural complications	0.51	0.387629
Investigations	0.51	0.424084
Metabolism and nutrition disorders	0.52	0.241611
Musculoskeletal and connective tissue disorders	0.54	0.420804
Neoplasms benign, malignant and unspecified (incl cysts and polyps)	0.64	0.413793
Nervous system disorders	0.49	0.280609
Pregnancy, puerperium and perinatal conditions	0.58	0.428571
Product issues	0.62	0.285714
Psychiatric disorders	0.51	0.292208
Renal and urinary disorders	0.55	0.236842
Reproductive system and breast disorders	0.57	0.105263
Respiratory, thoracic and mediastinal disorders	0.49	0.452261
Skin and subcutaneous tissue disorders	0.48	0.611215
Social circumstances	0.56	0.428571
Surgical and medical procedures	0.59	0.204082
Vascular disorders	0.52	0.280000

Micro F1 (SOC-specific tau): 0.424
Macro F1 (SOC-specific tau): 0.343

Feature importance using PredictionValuesChange

	AGE_Y	WEIGHT_KG	HEIGHT_CM	GENDER_CODE	furosemide	cephalothin	fursemide	frusemide	cefalotin	methylol cefalexin lysinate	...	ceftriaxone, sodium, sesquaterhydrate	fiuticasone furoate	potassium (chlorure de)	erlosamide	secukinumab	umeclidinium bromide	mepolizumab	rupatadine fumarate	sb240563	foscarbidopa
Blood and lymphatic system disorders	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	...	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	4.459527	3.082797	0.000000
Cardiac disorders	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	4.839763	7.273185	0.000000	0.000000	...	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000
Congenital, familial and genetic disorders	51.190605	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	...	0.000000	0.000000	0.000000	2.139929	0.000000	1.176621	0.000000	0.000000	0.000000	0.000000
Ear and labyrinth disorders	11.188684	0.000000	3.330825	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	3.659899	...	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000
Endocrine disorders	20.374933	0.000000	0.000000	0.000000	0.000000	0.000000	5.293540	8.332070	0.000000	0.000000	...	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000
Eye disorders	14.575514	7.390783	3.519209	0.000000	0.000000	0.000000	0.000000	2.017537	0.000000	0.704794	...	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000
Gastrointestinal disorders	0.000000	0.000000	2.173889	4.500409	0.000000	0.000000	0.000000	0.000000	0.000000	2.370260	...	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000
General disorders and administration site conditions	8.021897	5.272861	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	1.878158	0.000000	...	0.000000	0.000000	0.000000	0.000000	0.000000	3.439844	0.000000	0.000000	0.000000	0.000000
Hepatobiliary disorders	6.778231	4.460415	0.000000	0.000000	1.644275	0.000000	2.863413	0.000000	0.000000	0.000000	...	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000
Immune system disorders	6.708706	0.000000	0.000000	0.000000	0.000000	0.000000	1.851871	0.000000	0.000000	0.000000	...	0.000000	0.000000	0.000000	0.000000	0.000000	3.150392	0.000000	0.000000	2.325935	0.000000
Infections and infestations	14.346198	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	1.256802	0.000000	...	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000
Injury, poisoning and procedural complications	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	3.277147	0.000000	...	0.000000	0.000000	0.000000	0.000000	2.916122	0.000000	0.000000	0.000000	0.000000	0.000000
Investigations	0.000000	9.218411	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	5.253211	0.000000	...	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000
Metabolism and nutrition disorders	2.272516	0.000000	0.000000	0.000000	2.396426	0.000000	2.944541	0.000000	0.000000	0.000000	...	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000
Musculoskeletal and connective tissue disorders	1.638148	5.480245	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	...	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000
Neoplasms benign, malignant and unspecified (incl cysts and polyps)	17.178638	5.256239	0.000000	0.000000	0.000000	4.358269	0.000000	0.000000	0.000000	0.000000	...	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000
Nervous system disorders	2.022654	2.628679	1.155378	0.000000	0.000000	0.000000	0.000000	0.000000	1.083173	0.000000	...	0.000000	0.000000	2.651204	0.000000	1.644933	0.000000	0.000000	0.000000	0.000000	0.000000
Pregnancy, puerperium and perinatal conditions	36.136092	8.499998	8.074786	18.888959	0.000000	0.000000	0.000000	0.000000	0.000000	4.017795	...	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000
Product issues	8.298264	7.102906	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	...	0.000000	0.000000	0.000000	0.000000	5.216178	0.000000	0.000000	0.000000	0.000000	1.889606
Psychiatric disorders	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	...	0.000000	5.649585	0.000000	0.000000	6.132805	34.188719	0.000000	0.000000	3.816234	0.000000
Renal and urinary disorders	5.647135	6.371883	0.000000	3.103513	0.000000	0.000000	10.988634	9.868067	0.000000	0.000000	...	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000
Reproductive system and breast disorders	21.022077	0.000000	10.121698	2.421774	0.000000	0.000000	0.000000	12.158317	0.000000	5.062537	...	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000
Respiratory, thoracic and mediastinal disorders	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	...	1.124268	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	3.362798	0.000000
Skin and subcutaneous tissue disorders	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	...	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000
Social circumstances	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	...	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	21.158381	0.000000
Surgical and medical procedures	4.398453	1.560009	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	...	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	5.384351	0.000000	9.766159	0.000000
Vascular disorders	0.000000	7.619086	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	...	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	0.000000	7.337759	0.000000	0.000000

27 rows × 229 columns

	AGE_Y	WEIGHT_KG	HEIGHT_CM	GENDER_CODE	furosemide	chlorpromazine	cephalothin	chlordiazepoxide hydrochloride	fursemide	hydralazine hydrochloride	...	prunus cerasus extract	prunus cerasus root	prunus cerasus bark	cilgavimab	tixagevimab	daratumumab (humax-cd38)	sigvotatug vedotin	cephalosporin nos	ravulizumab
Blood and lymphatic system disorders	0.000000	0.000000	0.000000	0.000000	0.000000	0.0	0.000000	0.0	0.000000	0.0	...	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Cardiac disorders	0.000000	0.000000	0.000000	0.000000	0.000000	0.0	0.000000	0.0	4.839763	0.0	...	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Congenital, familial and genetic disorders	51.190605	0.000000	0.000000	0.000000	0.000000	0.0	0.000000	0.0	0.000000	0.0	...	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ear and labyrinth disorders	11.188684	0.000000	3.330825	0.000000	0.000000	0.0	0.000000	0.0	0.000000	0.0	...	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Endocrine disorders	20.374933	0.000000	0.000000	0.000000	0.000000	0.0	0.000000	0.0	5.293540	0.0	...	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Eye disorders	14.575514	7.390783	3.519209	0.000000	0.000000	0.0	0.000000	0.0	0.000000	0.0	...	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Gastrointestinal disorders	0.000000	0.000000	2.173889	4.500409	0.000000	0.0	0.000000	0.0	0.000000	0.0	...	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
General disorders and administration site conditions	8.021897	5.272861	0.000000	0.000000	0.000000	0.0	0.000000	0.0	0.000000	0.0	...	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Hepatobiliary disorders	6.778231	4.460415	0.000000	0.000000	1.644275	0.0	0.000000	0.0	2.863413	0.0	...	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Immune system disorders	6.708706	0.000000	0.000000	0.000000	0.000000	0.0	0.000000	0.0	1.851871	0.0	...	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Infections and infestations	14.346198	0.000000	0.000000	0.000000	0.000000	0.0	0.000000	0.0	0.000000	0.0	...	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Injury, poisoning and procedural complications	0.000000	0.000000	0.000000	0.000000	0.000000	0.0	0.000000	0.0	0.000000	0.0	...	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Investigations	0.000000	9.218411	0.000000	0.000000	0.000000	0.0	0.000000	0.0	0.000000	0.0	...	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Metabolism and nutrition disorders	2.272516	0.000000	0.000000	0.000000	2.396426	0.0	0.000000	0.0	2.944541	0.0	...	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Musculoskeletal and connective tissue disorders	1.638148	5.480245	0.000000	0.000000	0.000000	0.0	0.000000	0.0	0.000000	0.0	...	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Neoplasms benign, malignant and unspecified (incl cysts and polyps)	17.178638	5.256239	0.000000	0.000000	0.000000	0.0	4.358269	0.0	0.000000	0.0	...	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Nervous system disorders	2.022654	2.628679	1.155378	0.000000	0.000000	0.0	0.000000	0.0	0.000000	0.0	...	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Pregnancy, puerperium and perinatal conditions	36.136092	8.499998	8.074786	18.888959	0.000000	0.0	0.000000	0.0	0.000000	0.0	...	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Product issues	8.298264	7.102906	0.000000	0.000000	0.000000	0.0	0.000000	0.0	0.000000	0.0	...	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Psychiatric disorders	0.000000	0.000000	0.000000	0.000000	0.000000	0.0	0.000000	0.0	0.000000	0.0	...	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Renal and urinary disorders	5.647135	6.371883	0.000000	3.103513	0.000000	0.0	0.000000	0.0	10.988634	0.0	...	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reproductive system and breast disorders	21.022077	0.000000	10.121698	2.421774	0.000000	0.0	0.000000	0.0	0.000000	0.0	...	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Respiratory, thoracic and mediastinal disorders	0.000000	0.000000	0.000000	0.000000	0.000000	0.0	0.000000	0.0	0.000000	0.0	...	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Skin and subcutaneous tissue disorders	0.000000	0.000000	0.000000	0.000000	0.000000	0.0	0.000000	0.0	0.000000	0.0	...	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Social circumstances	0.000000	0.000000	0.000000	0.000000	0.000000	0.0	0.000000	0.0	0.000000	0.0	...	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Surgical and medical procedures	4.398453	1.560009	0.000000	0.000000	0.000000	0.0	0.000000	0.0	0.000000	0.0	...	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Vascular disorders	0.000000	7.619086	0.000000	0.000000	0.000000	0.0	0.000000	0.0	0.000000	0.0	...	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0

27 rows × 9093 columns