Pivoted full data¶
En este documento se crean las tablas para las predicciones.
| AGE_Y | WEIGHT_KG | HEIGHT_CM | GENDER_CODE | furosemide | chlorpromazine | cephalothin | chlordiazepoxide hydrochloride | fursemide | hydralazine hydrochloride | ... | Pregnancy, puerperium and perinatal conditions | Product issues | Psychiatric disorders | Renal and urinary disorders | Reproductive system and breast disorders | Respiratory, thoracic and mediastinal disorders | Skin and subcutaneous tissue disorders | Social circumstances | Surgical and medical procedures | Vascular disorders | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| REPORT_ID | |||||||||||||||||||||
| 164 | 68.0 | 47.000000 | 173.00 | 0 | 1 | 1 | 2 | 2 | 1 | 1 | ... | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 173 | 42.0 | 82.000000 | 180.00 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | ... | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 180 | 29.0 | 77.652228 | 165.00 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | ... | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 346 | 59.0 | 62.400000 | 159.70 | 1 | 0 | 0 | 2 | 0 | 0 | 0 | ... | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
| 356 | 21.0 | 60.000000 | 164.52 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | ... | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
5 rows × 9120 columns
<class 'pandas.core.frame.DataFrame'> Index: 17854 entries, 164 to 908149644 Columns: 9093 entries, AGE_Y to dtypes: float64(3), int32(2), uint32(9088) memory usage: 619.6 MB None <class 'pandas.core.frame.DataFrame'> Index: 17854 entries, 164 to 908149644 Columns: 9093 entries, AGE_Y to dtypes: float64(3), int8(9090) memory usage: 155.3 MB None
| Blood and lymphatic system disorders | Cardiac disorders | Congenital, familial and genetic disorders | Ear and labyrinth disorders | Endocrine disorders | Eye disorders | Gastrointestinal disorders | General disorders and administration site conditions | Hepatobiliary disorders | Immune system disorders | ... | Pregnancy, puerperium and perinatal conditions | Product issues | Psychiatric disorders | Renal and urinary disorders | Reproductive system and breast disorders | Respiratory, thoracic and mediastinal disorders | Skin and subcutaneous tissue disorders | Social circumstances | Surgical and medical procedures | Vascular disorders | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| REPORT_ID | |||||||||||||||||||||
| 164 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | ... | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 173 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | ... | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 180 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | ... | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 346 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | ... | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
| 356 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | ... | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
5 rows × 27 columns
| AGE_Y | WEIGHT_KG | HEIGHT_CM | GENDER_CODE | furosemide | chlorpromazine | cephalothin | chlordiazepoxide hydrochloride | fursemide | hydralazine hydrochloride | ... | prunus cerasus extract | prunus cerasus root | prunus cerasus bark | cilgavimab | tixagevimab | daratumumab (humax-cd38) | sigvotatug vedotin | cephalosporin nos | ravulizumab | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| REPORT_ID | |||||||||||||||||||||
| 164 | 68.0 | 47.000000 | 173.00 | 0 | 1 | 1 | 2 | 2 | 1 | 1 | ... | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 173 | 42.0 | 82.000000 | 180.00 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | ... | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 180 | 29.0 | 77.652228 | 165.00 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | ... | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 346 | 59.0 | 62.400000 | 159.70 | 1 | 0 | 0 | 2 | 0 | 0 | 0 | ... | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 356 | 21.0 | 60.000000 | 164.52 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | ... | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
5 rows × 9093 columns
Model¶
Number of features: 9093, Number of SOCs: 27
=== Training model for SOC: Blood and lymphatic system disorders (1/27) === 0: test: 0.6263969 best: 0.6263969 (0) total: 42.4ms remaining: 170ms 4: test: 0.7170507 best: 0.7170507 (4) total: 84.5ms remaining: 0us bestTest = 0.7170507014 bestIteration = 4 === Training model for SOC: Cardiac disorders (2/27) === 0: test: 0.6296576 best: 0.6296576 (0) total: 7.47ms remaining: 29.9ms 4: test: 0.7043951 best: 0.7043951 (4) total: 34.8ms remaining: 0us bestTest = 0.7043951452 bestIteration = 4 === Training model for SOC: Congenital, familial and genetic disorders (3/27) === 0: test: 0.7595760 best: 0.7595760 (0) total: 9.3ms remaining: 37.2ms 4: test: 0.8402794 best: 0.8434915 (3) total: 41.7ms remaining: 0us bestTest = 0.8434915245 bestIteration = 3 Shrink model to first 4 iterations. === Training model for SOC: Ear and labyrinth disorders (4/27) === 0: test: 0.6930045 best: 0.6930045 (0) total: 7.63ms remaining: 30.5ms 4: test: 0.6857546 best: 0.6973837 (2) total: 38.3ms remaining: 0us bestTest = 0.6973837316 bestIteration = 2 Shrink model to first 3 iterations. === Training model for SOC: Endocrine disorders (5/27) === 0: test: 0.7711140 best: 0.7711140 (0) total: 8.55ms remaining: 34.2ms 4: test: 0.8200512 best: 0.9286556 (2) total: 41.5ms remaining: 0us bestTest = 0.9286555648 bestIteration = 2 Shrink model to first 3 iterations. === Training model for SOC: Eye disorders (6/27) === 0: test: 0.6487707 best: 0.6487707 (0) total: 8.47ms remaining: 33.9ms 4: test: 0.6980752 best: 0.6980752 (4) total: 40.7ms remaining: 0us bestTest = 0.6980751753 bestIteration = 4 === Training model for SOC: Gastrointestinal disorders (7/27) === 0: test: 0.5854751 best: 0.5854751 (0) total: 26.1ms remaining: 105ms 4: test: 0.6118187 best: 0.6156444 (3) total: 128ms remaining: 0us bestTest = 0.6156444252 bestIteration = 3 Shrink model to first 4 iterations. === Training model for SOC: General disorders and administration site conditions (8/27) === 0: test: 0.6391513 best: 0.6391513 (0) total: 22.1ms remaining: 88.5ms 4: test: 0.6529090 best: 0.6580369 (3) total: 112ms remaining: 0us bestTest = 0.6580368876 bestIteration = 3 Shrink model to first 4 iterations. === Training model for SOC: Hepatobiliary disorders (9/27) === 0: test: 0.6869444 best: 0.6869444 (0) total: 23.9ms remaining: 95.8ms 4: test: 0.7036905 best: 0.7036905 (4) total: 118ms remaining: 0us bestTest = 0.7036904991 bestIteration = 4 === Training model for SOC: Immune system disorders (10/27) === 0: test: 0.6784772 best: 0.6784772 (0) total: 17.9ms remaining: 71.4ms 4: test: 0.7141991 best: 0.7141991 (4) total: 90.1ms remaining: 0us bestTest = 0.7141990662 bestIteration = 4 === Training model for SOC: Infections and infestations (11/27) === 0: test: 0.7119369 best: 0.7119369 (0) total: 11.6ms remaining: 46.5ms 4: test: 0.7292608 best: 0.7292608 (4) total: 53.8ms remaining: 0us bestTest = 0.7292607725 bestIteration = 4 === Training model for SOC: Injury, poisoning and procedural complications (12/27) === 0: test: 0.7072273 best: 0.7072273 (0) total: 11.4ms remaining: 45.8ms 4: test: 0.7511556 best: 0.7511556 (4) total: 44.7ms remaining: 0us bestTest = 0.7511556447 bestIteration = 4 === Training model for SOC: Investigations (13/27) === 0: test: 0.7063534 best: 0.7063534 (0) total: 9.61ms remaining: 38.4ms 4: test: 0.7441803 best: 0.7441803 (4) total: 44ms remaining: 0us bestTest = 0.7441803217 bestIteration = 4 === Training model for SOC: Metabolism and nutrition disorders (14/27) === 0: test: 0.6128425 best: 0.6128425 (0) total: 23.9ms remaining: 95.6ms 4: test: 0.7083851 best: 0.7083851 (4) total: 134ms remaining: 0us bestTest = 0.7083850503 bestIteration = 4 === Training model for SOC: Musculoskeletal and connective tissue disorders (15/27) === 0: test: 0.7202743 best: 0.7202743 (0) total: 11.5ms remaining: 45.9ms 4: test: 0.7651218 best: 0.7651218 (4) total: 56.5ms remaining: 0us bestTest = 0.7651218176 bestIteration = 4 === Training model for SOC: Neoplasms benign, malignant and unspecified (incl cysts and polyps) (16/27) === 0: test: 0.7370589 best: 0.7370589 (0) total: 12ms remaining: 48.1ms 4: test: 0.7613381 best: 0.7613381 (4) total: 64.8ms remaining: 0us bestTest = 0.7613381147 bestIteration = 4 === Training model for SOC: Nervous system disorders (17/27) === 0: test: 0.5651106 best: 0.5651106 (0) total: 23.8ms remaining: 95.4ms 4: test: 0.5992123 best: 0.5992123 (4) total: 106ms remaining: 0us bestTest = 0.599212274 bestIteration = 4 === Training model for SOC: Pregnancy, puerperium and perinatal conditions (18/27) === 0: test: 0.8995284 best: 0.8995284 (0) total: 21.6ms remaining: 86.3ms 4: test: 0.9462472 best: 0.9485448 (2) total: 98.9ms remaining: 0us bestTest = 0.9485448301 bestIteration = 2 Shrink model to first 3 iterations. === Training model for SOC: Product issues (19/27) === 0: test: 0.6886626 best: 0.6886626 (0) total: 10.3ms remaining: 41.2ms 4: test: 0.7354512 best: 0.7354512 (4) total: 48.8ms remaining: 0us bestTest = 0.7354512215 bestIteration = 4 === Training model for SOC: Psychiatric disorders (20/27) === 0: test: 0.6236721 best: 0.6236721 (0) total: 13.9ms remaining: 55.5ms 4: test: 0.6502540 best: 0.6585685 (3) total: 59.7ms remaining: 0us bestTest = 0.6585685164 bestIteration = 3 Shrink model to first 4 iterations. === Training model for SOC: Renal and urinary disorders (21/27) === 0: test: 0.7074958 best: 0.7074958 (0) total: 23.8ms remaining: 95.2ms 4: test: 0.7328501 best: 0.7328501 (4) total: 111ms remaining: 0us bestTest = 0.7328501344 bestIteration = 4 === Training model for SOC: Reproductive system and breast disorders (22/27) === 0: test: 0.7315862 best: 0.7315862 (0) total: 21.6ms remaining: 86.6ms 4: test: 0.7723102 best: 0.7833396 (2) total: 99.9ms remaining: 0us bestTest = 0.7833396196 bestIteration = 2 Shrink model to first 3 iterations. === Training model for SOC: Respiratory, thoracic and mediastinal disorders (23/27) === 0: test: 0.6767372 best: 0.6767372 (0) total: 14.3ms remaining: 57.4ms 4: test: 0.7035421 best: 0.7035421 (4) total: 70.5ms remaining: 0us bestTest = 0.7035420537 bestIteration = 4 === Training model for SOC: Skin and subcutaneous tissue disorders (24/27) === 0: test: 0.6928557 best: 0.6928557 (0) total: 22.6ms remaining: 90.5ms 4: test: 0.7098036 best: 0.7098036 (4) total: 108ms remaining: 0us bestTest = 0.7098036408 bestIteration = 4 === Training model for SOC: Social circumstances (25/27) === 0: test: 0.7419802 best: 0.7419802 (0) total: 18.2ms remaining: 72.7ms 4: test: 0.7535817 best: 0.7964436 (1) total: 99.8ms remaining: 0us bestTest = 0.7964435518 bestIteration = 1 Shrink model to first 2 iterations. === Training model for SOC: Surgical and medical procedures (26/27) === 0: test: 0.6967070 best: 0.6967070 (0) total: 8.98ms remaining: 35.9ms 4: test: 0.7807937 best: 0.7807937 (4) total: 37.9ms remaining: 0us bestTest = 0.7807936668 bestIteration = 4 === Training model for SOC: Vascular disorders (27/27) === 0: test: 0.6177105 best: 0.6177105 (0) total: 17.6ms remaining: 70.4ms 4: test: 0.6484150 best: 0.6491412 (3) total: 84.7ms remaining: 0us bestTest = 0.6491412222 bestIteration = 3 Shrink model to first 4 iterations.
Metrics¶
| SOC | prevalence_valid | AUC | AP | F1_thr_0.5 | |
|---|---|---|---|---|---|
| 23 | Skin and subcutaneous tissue disorders | 0.406495 | 0.709804 | 0.631514 | 0.535088 |
| 7 | General disorders and administration site cond... | 0.336506 | 0.658037 | 0.526365 | 0.494327 |
| 6 | Gastrointestinal disorders | 0.217805 | 0.615644 | 0.346264 | 0.358238 |
| 10 | Infections and infestations | 0.208287 | 0.729261 | 0.412187 | 0.471969 |
| 22 | Respiratory, thoracic and mediastinal disorders | 0.184211 | 0.703542 | 0.444026 | 0.444149 |
| 12 | Investigations | 0.165174 | 0.744180 | 0.362319 | 0.418552 |
| 16 | Nervous system disorders | 0.148936 | 0.599212 | 0.245829 | 0.240000 |
| 11 | Injury, poisoning and procedural complications | 0.110302 | 0.751156 | 0.324896 | 0.376761 |
| 14 | Musculoskeletal and connective tissue disorders | 0.107503 | 0.765122 | 0.351955 | 0.391304 |
| 26 | Vascular disorders | 0.101904 | 0.649141 | 0.256053 | 0.275862 |
| 9 | Immune system disorders | 0.100224 | 0.714199 | 0.343235 | 0.339552 |
| 0 | Blood and lymphatic system disorders | 0.089026 | 0.717051 | 0.256670 | 0.281690 |
| 19 | Psychiatric disorders | 0.079507 | 0.658569 | 0.241618 | 0.268657 |
| 1 | Cardiac disorders | 0.061030 | 0.704395 | 0.227362 | 0.207059 |
| 13 | Metabolism and nutrition disorders | 0.059910 | 0.708385 | 0.210244 | 0.190889 |
| 20 | Renal and urinary disorders | 0.055431 | 0.732850 | 0.142909 | 0.191736 |
| 5 | Eye disorders | 0.041993 | 0.698075 | 0.266146 | 0.150000 |
| 3 | Ear and labyrinth disorders | 0.028555 | 0.697384 | 0.307482 | 0.222222 |
| 25 | Surgical and medical procedures | 0.020717 | 0.780794 | 0.128172 | 0.119122 |
| 8 | Hepatobiliary disorders | 0.020157 | 0.703690 | 0.180186 | 0.085437 |
Validation¶
Micro F1 (thr=0.75): 0.003 Macro F1 (thr=0.75): 0.002 False Positives (thr=0.75): 0 False Positive Rate (thr=0.75): 0.000 True Negative Rate (thr=0.75): 1.000 Positive Predictive Value (thr=0.75): 1.000 Accuracy (thr=0.75): 0.000
Max FPR: 1.000, at threshold 0.000 Max TNR: 1.000, at threshold 0.727 Max PPV: 1.000, at threshold 0.727 Max Macro F1: 0.256, at threshold 0.535 Max Micro F1: 0.330, at threshold 0.515 Max Accuracy: 0.074, at threshold 0.576
Best treshold for each one¶
| best_tau | best_F1 | |
|---|---|---|
| SOC | ||
| Blood and lymphatic system disorders | 0.52 | 0.294118 |
| Cardiac disorders | 0.54 | 0.244444 |
| Congenital, familial and genetic disorders | 0.64 | 0.250000 |
| Ear and labyrinth disorders | 0.62 | 0.354839 |
| Endocrine disorders | 0.64 | 0.307692 |
| Eye disorders | 0.56 | 0.333333 |
| Gastrointestinal disorders | 0.49 | 0.376701 |
| General disorders and administration site conditions | 0.49 | 0.528503 |
| Hepatobiliary disorders | 0.58 | 0.222222 |
| Immune system disorders | 0.55 | 0.378531 |
| Infections and infestations | 0.50 | 0.471969 |
| Injury, poisoning and procedural complications | 0.51 | 0.387629 |
| Investigations | 0.51 | 0.424084 |
| Metabolism and nutrition disorders | 0.52 | 0.241611 |
| Musculoskeletal and connective tissue disorders | 0.54 | 0.420804 |
| Neoplasms benign, malignant and unspecified (incl cysts and polyps) | 0.64 | 0.413793 |
| Nervous system disorders | 0.49 | 0.280609 |
| Pregnancy, puerperium and perinatal conditions | 0.58 | 0.428571 |
| Product issues | 0.62 | 0.285714 |
| Psychiatric disorders | 0.51 | 0.292208 |
| Renal and urinary disorders | 0.55 | 0.236842 |
| Reproductive system and breast disorders | 0.57 | 0.105263 |
| Respiratory, thoracic and mediastinal disorders | 0.49 | 0.452261 |
| Skin and subcutaneous tissue disorders | 0.48 | 0.611215 |
| Social circumstances | 0.56 | 0.428571 |
| Surgical and medical procedures | 0.59 | 0.204082 |
| Vascular disorders | 0.52 | 0.280000 |
Micro F1 (SOC-specific tau): 0.424 Macro F1 (SOC-specific tau): 0.343
Feature importance using PredictionValuesChange¶
| AGE_Y | WEIGHT_KG | HEIGHT_CM | GENDER_CODE | furosemide | cephalothin | fursemide | frusemide | cefalotin | methylol cefalexin lysinate | ... | ceftriaxone, sodium, sesquaterhydrate | fiuticasone furoate | potassium (chlorure de) | erlosamide | secukinumab | umeclidinium bromide | mepolizumab | rupatadine fumarate | sb240563 | foscarbidopa | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Blood and lymphatic system disorders | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | ... | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 4.459527 | 3.082797 | 0.000000 |
| Cardiac disorders | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 4.839763 | 7.273185 | 0.000000 | 0.000000 | ... | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 |
| Congenital, familial and genetic disorders | 51.190605 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | ... | 0.000000 | 0.000000 | 0.000000 | 2.139929 | 0.000000 | 1.176621 | 0.000000 | 0.000000 | 0.000000 | 0.000000 |
| Ear and labyrinth disorders | 11.188684 | 0.000000 | 3.330825 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 3.659899 | ... | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 |
| Endocrine disorders | 20.374933 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 5.293540 | 8.332070 | 0.000000 | 0.000000 | ... | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 |
| Eye disorders | 14.575514 | 7.390783 | 3.519209 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 2.017537 | 0.000000 | 0.704794 | ... | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 |
| Gastrointestinal disorders | 0.000000 | 0.000000 | 2.173889 | 4.500409 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 2.370260 | ... | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 |
| General disorders and administration site conditions | 8.021897 | 5.272861 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 1.878158 | 0.000000 | ... | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 3.439844 | 0.000000 | 0.000000 | 0.000000 | 0.000000 |
| Hepatobiliary disorders | 6.778231 | 4.460415 | 0.000000 | 0.000000 | 1.644275 | 0.000000 | 2.863413 | 0.000000 | 0.000000 | 0.000000 | ... | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 |
| Immune system disorders | 6.708706 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 1.851871 | 0.000000 | 0.000000 | 0.000000 | ... | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 3.150392 | 0.000000 | 0.000000 | 2.325935 | 0.000000 |
| Infections and infestations | 14.346198 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 1.256802 | 0.000000 | ... | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 |
| Injury, poisoning and procedural complications | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 3.277147 | 0.000000 | ... | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 2.916122 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 |
| Investigations | 0.000000 | 9.218411 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 5.253211 | 0.000000 | ... | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 |
| Metabolism and nutrition disorders | 2.272516 | 0.000000 | 0.000000 | 0.000000 | 2.396426 | 0.000000 | 2.944541 | 0.000000 | 0.000000 | 0.000000 | ... | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 |
| Musculoskeletal and connective tissue disorders | 1.638148 | 5.480245 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | ... | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 |
| Neoplasms benign, malignant and unspecified (incl cysts and polyps) | 17.178638 | 5.256239 | 0.000000 | 0.000000 | 0.000000 | 4.358269 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | ... | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 |
| Nervous system disorders | 2.022654 | 2.628679 | 1.155378 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 1.083173 | 0.000000 | ... | 0.000000 | 0.000000 | 2.651204 | 0.000000 | 1.644933 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 |
| Pregnancy, puerperium and perinatal conditions | 36.136092 | 8.499998 | 8.074786 | 18.888959 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 4.017795 | ... | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 |
| Product issues | 8.298264 | 7.102906 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | ... | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 5.216178 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 1.889606 |
| Psychiatric disorders | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | ... | 0.000000 | 5.649585 | 0.000000 | 0.000000 | 6.132805 | 34.188719 | 0.000000 | 0.000000 | 3.816234 | 0.000000 |
| Renal and urinary disorders | 5.647135 | 6.371883 | 0.000000 | 3.103513 | 0.000000 | 0.000000 | 10.988634 | 9.868067 | 0.000000 | 0.000000 | ... | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 |
| Reproductive system and breast disorders | 21.022077 | 0.000000 | 10.121698 | 2.421774 | 0.000000 | 0.000000 | 0.000000 | 12.158317 | 0.000000 | 5.062537 | ... | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 |
| Respiratory, thoracic and mediastinal disorders | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | ... | 1.124268 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 3.362798 | 0.000000 |
| Skin and subcutaneous tissue disorders | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | ... | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 |
| Social circumstances | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | ... | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 21.158381 | 0.000000 |
| Surgical and medical procedures | 4.398453 | 1.560009 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | ... | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 5.384351 | 0.000000 | 9.766159 | 0.000000 |
| Vascular disorders | 0.000000 | 7.619086 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | ... | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 7.337759 | 0.000000 | 0.000000 |
27 rows × 229 columns
| AGE_Y | WEIGHT_KG | HEIGHT_CM | GENDER_CODE | furosemide | chlorpromazine | cephalothin | chlordiazepoxide hydrochloride | fursemide | hydralazine hydrochloride | ... | prunus cerasus extract | prunus cerasus root | prunus cerasus bark | cilgavimab | tixagevimab | daratumumab (humax-cd38) | sigvotatug vedotin | cephalosporin nos | ravulizumab | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Blood and lymphatic system disorders | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.0 | 0.000000 | 0.0 | 0.000000 | 0.0 | ... | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| Cardiac disorders | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.0 | 0.000000 | 0.0 | 4.839763 | 0.0 | ... | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| Congenital, familial and genetic disorders | 51.190605 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.0 | 0.000000 | 0.0 | 0.000000 | 0.0 | ... | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| Ear and labyrinth disorders | 11.188684 | 0.000000 | 3.330825 | 0.000000 | 0.000000 | 0.0 | 0.000000 | 0.0 | 0.000000 | 0.0 | ... | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| Endocrine disorders | 20.374933 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.0 | 0.000000 | 0.0 | 5.293540 | 0.0 | ... | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| Eye disorders | 14.575514 | 7.390783 | 3.519209 | 0.000000 | 0.000000 | 0.0 | 0.000000 | 0.0 | 0.000000 | 0.0 | ... | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| Gastrointestinal disorders | 0.000000 | 0.000000 | 2.173889 | 4.500409 | 0.000000 | 0.0 | 0.000000 | 0.0 | 0.000000 | 0.0 | ... | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| General disorders and administration site conditions | 8.021897 | 5.272861 | 0.000000 | 0.000000 | 0.000000 | 0.0 | 0.000000 | 0.0 | 0.000000 | 0.0 | ... | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| Hepatobiliary disorders | 6.778231 | 4.460415 | 0.000000 | 0.000000 | 1.644275 | 0.0 | 0.000000 | 0.0 | 2.863413 | 0.0 | ... | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| Immune system disorders | 6.708706 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.0 | 0.000000 | 0.0 | 1.851871 | 0.0 | ... | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| Infections and infestations | 14.346198 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.0 | 0.000000 | 0.0 | 0.000000 | 0.0 | ... | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| Injury, poisoning and procedural complications | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.0 | 0.000000 | 0.0 | 0.000000 | 0.0 | ... | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| Investigations | 0.000000 | 9.218411 | 0.000000 | 0.000000 | 0.000000 | 0.0 | 0.000000 | 0.0 | 0.000000 | 0.0 | ... | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| Metabolism and nutrition disorders | 2.272516 | 0.000000 | 0.000000 | 0.000000 | 2.396426 | 0.0 | 0.000000 | 0.0 | 2.944541 | 0.0 | ... | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| Musculoskeletal and connective tissue disorders | 1.638148 | 5.480245 | 0.000000 | 0.000000 | 0.000000 | 0.0 | 0.000000 | 0.0 | 0.000000 | 0.0 | ... | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| Neoplasms benign, malignant and unspecified (incl cysts and polyps) | 17.178638 | 5.256239 | 0.000000 | 0.000000 | 0.000000 | 0.0 | 4.358269 | 0.0 | 0.000000 | 0.0 | ... | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| Nervous system disorders | 2.022654 | 2.628679 | 1.155378 | 0.000000 | 0.000000 | 0.0 | 0.000000 | 0.0 | 0.000000 | 0.0 | ... | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| Pregnancy, puerperium and perinatal conditions | 36.136092 | 8.499998 | 8.074786 | 18.888959 | 0.000000 | 0.0 | 0.000000 | 0.0 | 0.000000 | 0.0 | ... | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| Product issues | 8.298264 | 7.102906 | 0.000000 | 0.000000 | 0.000000 | 0.0 | 0.000000 | 0.0 | 0.000000 | 0.0 | ... | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| Psychiatric disorders | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.0 | 0.000000 | 0.0 | 0.000000 | 0.0 | ... | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| Renal and urinary disorders | 5.647135 | 6.371883 | 0.000000 | 3.103513 | 0.000000 | 0.0 | 0.000000 | 0.0 | 10.988634 | 0.0 | ... | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| Reproductive system and breast disorders | 21.022077 | 0.000000 | 10.121698 | 2.421774 | 0.000000 | 0.0 | 0.000000 | 0.0 | 0.000000 | 0.0 | ... | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| Respiratory, thoracic and mediastinal disorders | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.0 | 0.000000 | 0.0 | 0.000000 | 0.0 | ... | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| Skin and subcutaneous tissue disorders | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.0 | 0.000000 | 0.0 | 0.000000 | 0.0 | ... | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| Social circumstances | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.0 | 0.000000 | 0.0 | 0.000000 | 0.0 | ... | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| Surgical and medical procedures | 4.398453 | 1.560009 | 0.000000 | 0.000000 | 0.000000 | 0.0 | 0.000000 | 0.0 | 0.000000 | 0.0 | ... | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| Vascular disorders | 0.000000 | 7.619086 | 0.000000 | 0.000000 | 0.000000 | 0.0 | 0.000000 | 0.0 | 0.000000 | 0.0 | ... | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
27 rows × 9093 columns